Antiedematogenic Activity of Two Thiazolidine Derivatives: N-Tryptophyl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene) Rhodanine (GS26) and N-Tryptophyl-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-2,4-thiazolidinedione (GS28)
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منابع مشابه
Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria.
[(3,5-Di-tert-butyl-4-hydroxybenzylidene)-malononitrile] (AG17), a "tyrphostin" tyrosine kinase antagonist, was found to inhibit tumor cell growth with 50% growth inhibition ranging from 0.7 to 4.0 microM in a panel of 13 human tumor cell lines, as evaluated by tetrazolium dye reduction and inhibition of precursor incorporation into macromolecules. The promyelocytic leukemia cell line HL-60(TB)...
متن کامل2,6-Di-tert-butyl-4-[(N-methylanilino)methyl]phenol
The title compound, C(22)H(31)NO, has been synthesized from 4-bromo-methyl-2,6-di-tert-butyl-phenol and N-methyl-aniline. There are two independent mol-ecules in the asymmetric unit. The aniline ring in each of the independent mol-ecules was found to be disordered, with site occupation factors 0.621 (10)/0.379 (10) and 0.605 (10)/0.395 (10).
متن کامل2-[(3,5-Di-tert-butyl-4-hydroxybenzyl)sulfanyl]-N′-isopropylideneacetohydrazide
The title compound, C(20)H(32)N(2)O(2)S, the condensation product of a thio-acetohydrazine and acetone, has a two-coordinate S atom and the angle at this atom is 100.7 (1)°. The (CH(3))C=N-NH-C(O)- substituent engages in N-H⋯O hydrogen-bonding inter-actions with the substituent of an adjacent mol-ecule across a center of inversion, generating a dimeric structure.
متن کامل2,6-Di-tert-butyl-4-(methoxymethyl)phenol
The title compound, C(16)H(26)O(2), was easily obtained in high yield when 4-bromo-methyl-2,6-di-tert-butyl-phenol was reacted with methanol. There are two independent mol-ecules in the asymmetric unit. The meth-oxy group in each of the independent mol-ecules was found to be disordered, with site-occupation factors of 0.8728 (18)/0.1272 (18) and 0.8781 (17)/0.1219 (17).
متن کامل2,4-Di-tert-butyl-6-[1-(3,5-di-tert-butyl-2-hydroxyphenyl)ethyl]phenyl 4-methylbenzenesulfonate
The title compound, C(37)H(52)O(4)S, was obtained by the reaction of 6,6'-(ethane-1,1-di-yl)bis-(2,4-di-tert-butyl-phenol) and 4-methyl-benzene-1-sulfonyl chloride. The mol-ecular conformation is stabilized by an intra-molecular O-H⋯O hydrogen bond. Two of the tert-butyl groups are disordered over two sets of sites with occupancies 0.530 (15)/0.470 (15) and 0.615 (11)/0.385 (11).
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2003
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.51.1351